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. 2011 Dec 16;6(12):e28901. doi: 10.1371/journal.pone.0028901

Figure 1. Adaption process of each passage of mouse-adapted seasonal H1N1 A/Brisbane/59/2007 viruses in mouse lungs.

Figure 1

BALB/c mice were infected with wild-type virus and three days later, their lungs were dissected out to generate the first passage of mouse-adapted virus (MA-1). Subsequently, the lung lysates were used for infection of mice to generate MA-2, which was subjected serial mouse lung passages (total of eight passages). The replication of each passaged virus was determined as viral titers in the lungs. Data are expressed as mean ± SD of viral titers (log10 PFU/mg) in the lungs of each group of mice (n = 3 per group) from three separate experiments. * P<0.05 vs. the values of wild type virus.