Table 2. HIV-1 drug resistance in ARV-naïve subjects with primary HIV-1 infection.
2a: OLA versus consensus sequencing of plasma | 2b: OLA versus consensus sequencing of PBMC | 2c: Consensus sequencing of plasma versus PBMC | 2d: OLA of plasma versus PBMC | ||||||||||||
p = .0005 | OLA | p = .002 | OLA | p = 1.0 | PBMCs | p = 1.0 | PBMCs | ||||||||
− | + | − | + | − | + | − | + | ||||||||
sequencing | − | 83 | 12 | sequencing | − | 81 | 13 | plasma | − | 94 | 1 | plasma | − | 72 | 11 |
+ | 0 | 4 | + | 1 | 4 | + | 0 | 4 | + | 10 | 6 |
ARV: antiretroviral; OLA: oligonucleotide ligation assay; PBMC: peripheral blood mononuclear cells.
+ = subjects with ≥1 mutation or mixture.
− = subjects without mutations or with indeterminate results.
Numbers represent subjects in whom HIV-1 drug resistance was/was not detected in plasma and PBMC specimens that had been obtained a median of 29 (IQR 19–66) and 31 (IQR 19–66) days after HIV-1 infection, respectively; all specimens were collected within six months of infection. McNemar's exact tests compare only subjects with discordant results (indicated in bold).