Fig. 2.

H-PGDS–dependent PGD₂ production from bone marrow-derived cells decreases angiogenesis and vascular permeability in tumors. Tumor sections were subjected to immunostaining and then counterstained with DAPI (A and D) (Scale bars: A and D, 50 μm). Angiogenic area (PECAM-1) was quantified relative to total pixel density (B). Fibrinogen deposition was normalized to total PECAM-1⁺ pixel density (C, n = 6–10). The pixel density of α-SMA was normalized to total PECAM-1⁺ pixel density (E, n = 6 each). Dye extravasations (30 min) into tumor were quantified (F, n = 8 each). *^†P < 0.05 compared with WT or H-PGDS^−/−.