Fig. P1.

Potential mechanism of Yta7's limitation of chromatin-bound H3. Our data supported a model in which Yta7 is recruited to highly transcribed genes, where it is necessary to limit the amount and distribution of H3 occupancy. As depicted, transcriptional defects attributable to the increased nucleosome occupancy in cells without Yta7 were suppressed by decreasing the dosage of H3 and H4, (hht1-hhf1)Δ. Only four of the eight histones within a nucleosome are depicted for clarity. Boxes represent gene bodies, and arrow width indicates the extent of transcription. PolII, RNA Polymerase II.