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. 2011 Nov 21;108(49):E1293-E1301. doi: 10.1073/pnas.1111471108

Fig. 7.

Fig. 7.

Two examples of contact map predictions using MI (A and D) and mfDCA (B and E). Gray symbols represent the native map with a cutoff of 8 Å, colored symbols the computational contact predictions using MI or DI ranking (red squares for TP and green squares for spatially distant pairs). The number of pairs is determined such that there are 2L pairs with minimum separation five along the sequence, where L is the domain length. The right-most panels (C and F) bin the predictions of MI (blue) and mfDCA (red) according to their separation along the protein sequence. The overall bars count all predictions, the shaded part the TPs. Note in particular that mfDCA leads to a higher number of more accurate predictions for large separations. (A–C) The promoter recognition helix domain of the SigmaE factor (PDB ID 1OR7). (D–F) The eukaryotic signaling protein Ras (PDB ID 1P21). For better comparability of native vs. predicted contacts, the predictions are displayed only above the diagonal.