Table 1.

Cohort-wise association test results for 14 representative SNPs

			Discovery			JP2 (Replication 1)			JP1 (Replication 2)
Chromosome	SNP	Position	RA	P	PPA	RA	P	log10(BF)	RA	P	log10(BF)
1p36.31	rs1876848	6,876,262	G	2.0E-05	0.1128	A	0.016	0.61	NA
1p22.2	rs1725390	91,031,160	A	2.0E-05	0.1011	A	0.14	−0.11	A	0.59	−0.40
1q21.3	rs905938	153,258,013	T	1.7E-05	0.1252	T	0.62	−0.18	T	0.82	−0.15
2q33.1*	rs787994	197,931,366	T	2.1E-05	0.0988	C	8.6E-05	2.51	T	0.070	0.19
4q31.23	rs6841581	148,620,640	G	1.1E-05	0.1750	G	0.0066	0.93	G	0.023	0.53
5q23.2	rs2287696	122,488,231	A	1.1E-05	0.1760	A	0.27	−0.32	NA
8p23.2	rs2045637	2,963,188	A	8.6E-06	0.2139	G	0.36	−0.38	NA
8q24.23*	rs1554349	139,604,536	A	7.9E-05	0.0349	A	0.15	−0.12	G	0.33	−0.28
11q22.2	rs2124216	101,644,113	A	9.1E-06	0.1963	A	0.20	−0.24	G	0.65	−0.43
12p13.31	rs728342	5,577,633	G	1.2E-05	0.1601	G	0.33	−0.30	G	0.56	−0.33
12q22	rs6538595	94,030,754	A	1.8E-05	0.1136	A	0.0051	1.01	A	0.13	−0.012
19q13.12	rs1688005	40,340,205	G	1.6E-05	0.1244	T	0.16	−0.069	NA
20p12.1	rs1132274	17,544,155	A	1.5E-05	0.1435	A	0.012	0.69	NA†
22q12.1	rs133885	24,489,289	G	1.6E-05	0.1230	G	0.67	−0.42	NA

Genomic positions were based on the human genome build 36. NA, the SNP was not genotyped. RA, risk allele aligned to the forward strand of the reference genome.

*For these loci, the lead SNPs were not genotyped (see Methods).

^†Genotyping of rs1132274 in the JP1 cohort failed.