Table 2.
Chromosome | SNP | Position | Gene | RA | Cohort | P value | log10 (BF) | PPA | OR (95% CI) |
4q31.23 | rs6841581 | 148,620,640 | EDNRA | G | Discovery | 1.1E-05 | 3.33 | 0.1750 | 1.25 (1.13–1.39) |
G | Replication | 0.00042 | 1.93 | 1.20 (1.08–1.32) | |||||
Combined | 2.2E-08 | 5.84 | 0.9857 | 1.22 (1.14–1.31) | |||||
12q22 | rs6538595 | 94,030,754 | NDUFA12/NR2C1/FGD6/VEZT | A | Discovery | 1.8E-05 | 3.11 | 0.1136 | 1.16 (1.08–1.24) |
A | Replication | 0.0017 | 1.38 | 1.16 (1.06–1.28) | |||||
Combined | 1.1E-07 | 5.15 | 0.9343 | 1.16 (1.10–1.23) | |||||
20p12.1 | rs1132274 | 17,544,155 | RRBP1 | A | Discovery | 1.5E-05 | 3.22 | 0.1435 | 1.22 (1.11–1.33) |
A | Replication (JP2) | 0.012 | 0.69 | 1.16 (1.03–1.30) | |||||
Combined | 6.9E-07 | 4.43 | 0.7279 | 1.20 (1.11–1.28) |
Genomic positions were based on the human genome build 36. OR, the per-allele odds ratio of the risk allele; RA, risk allele aligned to the forward strand of the reference genome. Replication and combined results are based on the fixed-effects model.