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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Int J Biochem Cell Biol. 2011 Oct 25;44(1):158–169. doi: 10.1016/j.biocel.2011.10.011

Figure 10. Proposed mechanism of ET-1 regulation of myofibroblast susceptibility to apoptosis by upregulation of Survivin.

Figure 10

Endothelin-1 binding to its cognate receptors, ET-A and ET-B leads to the Rho-GTPase and ROCK-dependent activation of FAK. FAK activation then induces activation of PI3K and AKT, with the resultant increase in Survivin expression. Increased Survivin expression promotes myofibroblast resistance to apoptosis.