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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Gene Ther. 2011 Sep 15;19(7):724–733. doi: 10.1038/gt.2011.126

Figure 5. Gene delivery of IL-10 improves memory function of APP+PS1 mice.

Figure 5

(a, b) APP+PS1 mice received bilateral hippocampal injections of AAV-GFP or AAV-IL-10 at 3 months of age and were tested by the 2-day RAWM task at 7 months of age. Non-tg serves as a positive control for the spatial learning task. The compiled average errors (a) and latency (b) are shown. Bars represent mean ± SEM (n = 9 per group). P-values for the variances between Tg/AAV-GFP vs. Tg/AAV-IL-10 are < 0.0001 for time, column factor, and < 0.001 for subject matching (for errors) and < 0.0001 for time, column factor, and subject matching (for latency) as determined by two-way ANOVA and Bonferroni tests. (c) Measurement of average swimming speed of animals. Average swimming speed through the training was equivalent on all mice groups. N.D. denotes no significant difference, as determined by one-way ANOVA and Newman–Keules post-test. Error bars represent SEM (n = 9 per group).