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. Author manuscript; available in PMC: 2012 Dec 21.
Published in final edited form as: J Am Chem Soc. 2011 Nov 30;133(50):20571–20580. doi: 10.1021/ja208972h

Figure 2.

Figure 2

(A) Sequence and topology plot for the CD147 transmembrane/cytosolic domain. (B) SDS-PAGE gel with Coomassie staining of the purified CD147-CTD. (C) Sequence and topology plot for C99. (D) Sequence alignments for the transmembrane domains of human C99 and human CD147-CTD. The γ-secretase cleavage sites at C99 for production of Aβ40 and Aβ42 are highlighted in red. The unusual glutamic acid in the CD147 transmembrane domain is highlighted in green. The transmembrane sequence of CD147 is highly conserved among all species.