Skip to main content
. Author manuscript; available in PMC: 2012 Dec 21.
Published in final edited form as: J Am Chem Soc. 2011 Nov 22;133(50):20052–20055. doi: 10.1021/ja208050t

Figure 2.

Figure 2

‘Carving out’ the pKSI oxyanion hole. A) Schematic representation of oxyanion hole hydrogen bond donors (red), tyro-sine network (blue), and surrounding residues (green and black). The substrate is also shown in black. B) Rate effects from ablating neighboring side chains in the oxyanion hole mutant background. Values are from Table S1. Bars and residues are colored according to panel A.