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. Author manuscript; available in PMC: 2012 Dec 21.
Published in final edited form as: J Am Chem Soc. 2011 Nov 30;133(50):20611–20622. doi: 10.1021/ja209244m

Table 12.

Reductive Cyclization of 37

graphic file with name nihms338081u12.jpg
entry [H−] conditions % yielda
1 37q, 10 equiv LiHBEt3, THF 50 (81)
2 37q, 5 equiv DIBAL, CH2Cl2; MeOH/Et2O, SiO2, rt 43 (52)
3 37q, 6 equiv DIBAL/6 equiv n-BuLi, THF; MeOH/THF, SiO2, rt 85
4 37r, 6 equiv DIBAL/6 equiv n-BuLi, THF; MeOH/THF, SiO2, rt 71
a

Isolated yield. Number in parantheses refers to yield based on recovered 37.