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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Nat Chem Biol. 2011 Nov 27;8(1):125–132. doi: 10.1038/nchembio.721

Figure 6. Role of mitochondria and Fe-S cluster biogenesis in nuclear DNA replication.

Figure 6

Assembly of Fe-S clusters on nuclear replicative DNA polymerases requires Fe-S protein biogenesis machineries located in the mitochondria (Iron-Sulfur Cluster assembly, ISC machinery) and cytosol (Cytosolic Iron-sulfur protein Assembly, CIA machinery) providing an explanation for the essential function of mitochondria for cell viability.