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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Arthritis Rheum. 2012 Jan;64(1):272–280. doi: 10.1002/art.30647

Figure 1.

Figure 1

A. IGFBP-3 siRNA (siBP-3) blocks TGF-β-induced TN-C expression in primary human fibroblasts. Primary lung fibroblasts in passage 3–5 were transfected with siRNA with or without subsequent stimulation with TGF-β. Conditioned media were collected after 48hrs and evaluated for TN-C expression by western blot (n = 3). IGFBP-3 siRNA efficiently and specifically silenced IGFBP-3 and showed no effect on TGF-β-induced collagen expression (LFN = lipofectamine). B. Graphical presentation of data shown in panel A (TN-C). Data are shown as ratios to baseline TN-C expression. * p = 0.004; ** p = 0.011.