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. Author manuscript; available in PMC: 2012 Dec 13.
Published in final edited form as: Cancer Cell. 2011 Dec 13;20(6):741–754. doi: 10.1016/j.ccr.2011.10.030

Figure 3. β-catenin signaling controls the ability of melanomas to metastasize to lung, bowel, and spleen.

Figure 3

(A) Lungs from a perinatally treated Pten/Braf/Bcat-STA mouse at 27 days of age (left panel) and a perinatally treated Pten/Braf/Bcat-KO mouse at 56 days of age (right panel).

(B) Comparison of number of lung metastases visible on the surface of the lung in perinatally treated litters. Error bars represent SEM.

(C) Lung metastasis from a perinatally treated Pten/Braf/Bcat-STA mouse, scale 100 μM.

(D) Bowel metastasis from a perinatally treated Pten/Braf/Bcat-STA mouse.

(E) Comparison of number of bowel metastases in perinatally treated litters.

(F) H&E stained spleen metastasis from a perinatally treated Pten/Braf/Bcat-STA mouse, scale 200 μM.

(G) Comparison of number of spleen metastases in perinatally treated litters.

See also Figure S2.