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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Expert Rev Respir Med. 2011 Oct;5(5):683–697. doi: 10.1586/ers.11.51

Figure 2. Silencing mechanism of simian virus 40 late gene transcription.

Figure 2

Early genes transcripts extend beyond poly A signal and overlap the late gene region (light gray), leading to late gene antisense RNA. The resulting double-strand RNA is degraded, impairing late gene expression.

EP: Early promoter; gDNA: Genomic DNA; LP: Late promoter.