Table I.
SHE pH 6.7 | SHE pH 7.0 | BALB/c 3T3 | C3H10T1/2 | |
Concordancea (%) | 74 | 85 | 68 | 84 |
Sensitivity (%) | 66 | 92 | 75 | 72 |
Specificity (%) | 85 | 66 | 53 | 80 |
Positive predictivity | 88 | 88 | 77 | 95 |
Negative predictivity | 62 | 75 | 50 | 34 |
False-positive rate | 15 | 34 | 47 | 20 |
False-negative rate | 33 | 08 | 25 | 28 |
Number of chemicals | 88 | 204 | 149 | 96 |
Number of carcinogens (%) | 54 (61) | 142 (74) | 100 (68) | 81 (84) |
Concordance = agreement between rodent carcinogenicity and CTA results.