Fig. 2.

Cardiac Z disk/titin cytoskeletal structure-associated proteins. An increasing number of molecules have been identified on or in the vicinity of cardiac Z disk/titin cytoskeleton. Many of these proteins have been linked to intrinsic mechanical sensor sensor/signal modulator functions. See text for details. MYOZ2, myozenin 2 (carsarin 1); Cn, calcineurin; PDZ-3LIM, one-PDZ and three-LIM domain protein; PDZ-1LIM, one-PDZ and one-LIM domain protein; MLP/CRP3, muscle-specific LIM protein/cysteine-rich protein 3; FHL2, four-and-a-half LIM protein 2; MAPRs, muscle ankyrin repeat proteins; MURFs, muscle-specific ring-finger proteins.