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. Author manuscript; available in PMC: 2011 Dec 18.
Published in final edited form as: Cancer Res. 2009 Aug 11;69(17):7062–7070. doi: 10.1158/0008-5472.CAN-09-0476

Figure 3. Kp-10 inhibits tumor growth and tumor angiogenesis in xenograft mice.

Figure 3

(A) Kp-10 has little effect on tumor cell (PC-3) proliferation with 100 μM Kp-10 using Cell Titer96 AQueous One solution cell proliferation assay. (B) Treatment of Kp-10 inhibited tumor growth. Typical example of tumor-bearing mice of the PBS control (left) or Kp-10-treated groups (right) on day 45. Tumor was marked with a dot line. (C) Quantitative analysis of tumor volumes between PBS-treated and Kp-10-treated tumor and quantitative analysis of the mouse body weight between PBS-treated and Kp-10-treated mice during the treatment period. The tumor volume data are presented as mean ± SD (**, p<0.01). (D) Effects of Kp-10 on tumor angiogenesis in xenograft mouse tumor model. Tumors were fixed and embedded with paraffin. The 5 μm sections were stained with CD31 antibody. The average vessel number in tumors of control group was significantly more than that of Kp-10 treatment group (*, p<0.05).