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. Author manuscript; available in PMC: 2012 Oct 21.
Published in final edited form as: Mol Cell. 2011 Oct 21;44(2):214–224. doi: 10.1016/j.molcel.2011.07.040

Figure 4. Comparison of A-site tRNA contacts with 60S ribosomal subunit for all four sub-populations described.

Figure 4

(from top to the bottom: A, B, classical-1; C, D, classical-2; E, F, rotated-1; G, H rotated-2). (A, C, E, G) Illustration of different contacts between A-site tRNA and H69. (B, D, F, H) Demonstration of the potentially dynamic interaction between the A-site tRNA elbow and components of the 60S subunit during the transition from classical-1 to rotated-2 intermediate states. Models for rRNA and separated proteins are derived from the X-ray structure of the yeast 80S ribosome ((Ben-Shem et al., 2010) PDB ID 3O58)

See alsoFigure S4. Distinct features of 80S ribosomes in the classical-1 and classical-2 subpopulations.

Movie S1. Spontaneous movement of tRNAs relative to the 60S subunit.

Movie S2. Spontaneous movement of tRNAs relative to the 40S subunit.