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Trans-epidermal water loss (TEWL) values of each day after treatment of spantide II and ketoprofen comprising gel (SP+KP gel) and skin penetrating nanogel comprising ketoprofen (KP-SPN), spantide II (SP-SPN), a combination of spantide II and ketoprofen (SP+KP-SPN) along with a positive control, Topgraf® (tacrolimus ointment 0.1%) for 5 days on the back skin of C57/BL mice. Values represent mean ± SD, n = 6.
