Table 1.

Summary of notation

Haplotypes	ASN1	ASN2	ARN1	ARN2
Frequency	p1	p2	p3	p4
Fitness in	$W_1^{\left(U\right)}$	$W_2^{\left(U\right)}$	$W_3^{\left(U\right)}$	$W_4^{\left(U\right)}$
Untreated hosts	1	1	1 − s	1 − s
Fitness in	$W_1^{\left(T\right)}$	$W_2^{\left(T\right)}$	$W_3^{\left(T\right)}$	$W_4^{\left(T\right)}$
Treated hosts	1 − dS	1 − dS	1 − dR	1 − dR
Sensitive/resistant	Sen.	Sen.	Res.	Res.

The tables shows the notation of the four haplotypes, their frequencies, fitnesses in treated and untreated hosts, the parametrization of fitnesses that we are going to use for the illustrations in the following sections, and whether the haplotypes are sensitive or resistant. Here, s reflects metabolic costs of the resistant allele, while d_S and d_R indicate how efficiently the drug wipes out the sensitive and resistant parasites, respectively