Table 2.
Regulators of SIRT1 activity
| Routes | Regulators | Results | Mechanisms | References |
|---|---|---|---|---|
|
Protein-protein
interaction |
AROS | ↑ | Binds and enhances deacetylating activity to p53 |
Kim, 2007b |
| DBC-1 | ↓ | Interacts with leucine zipper motif and the catalytic domain |
Kim, 2008; Zhao, 2008 |
|
|
Post-
translational modification |
Sumo | ↑ | Sumoylation of Lys734 | Yang, 2007b |
| JNK1 | ↑ | Phosphorylation of Ser27 and Ser47 |
Beausoleil, 2004 | |
| DYRK1,3 | ↑ | Phosphorylation of Thr522 | Guo, 2010 | |
| CHK1 | ↑ | Phosphorylation of Thr530 and Thr540 |
Sasaki, 2008 | |
| CK2 | ↑ | Phosphorylation of Ser659 and Ser661 |
Zschoernig, 2009 | |
| MST1 | ↓ | Phosphorylation of C-terminus | Yuan, 2011 | |
| Pharmacological | Resveratrol | ↑ | Unclear |
Howitz, 2003; Wood, 2004 |
| Quercetin | ↑ | Unclear | de Boer, 2006 | |
| Sirtinol | ↓ | Interferes with body axis formation |
Grozinger, 2001 | |
| Splitomicin | ↓ | Inhibits the access of the acetylated lysines with SIER1 |
Bedalov, 2001 | |
| Oxidative | 4-HNE, acrolein |
↓ | Reacts with Cys467 and Cys692 | Caito, 2010 |
| Metabolic | NAD+ | ↑ | Substrate of sirtuins |
Vaziri, 2001; Araki, 2004 |
| Nicotinamide | ↓ | Switches between deacetylation and base exchange |
Sauve, 2001; Jackson, 2003 |
|
| ADP-ribose | ↓ | Unclear | Zhao, 2004 |