Table 1. Link between mutations in antigenic site and RBS residues for HA-escape mutants10. SA-anchoring RBS residues contained within the SIN of antigenic residues whose SIN score is generally higher than corresponding score in wild-type HA as a result of antigenic mutations that increase glycan-binding affinity are highlighted in yellow. Highlighted in cyan are SA-anchoring residues contained within the SIN of antigenic residues whose SIN score is generally lower than corresponding score in wild-type HA as a result of antigenic mutations that decrease glycan-binding affinity. In the case of mutations that do not alter the glycan-binding affinity, most of these residues do not have any SA-anchoring RBS residues in their SIN. The SA-anchoring RBS residues (whose SIN scores are not affected) are in the network of these antigenic mutations are shown in red text.
Emergent Mutation | SIN Score | RBS Residues in SIN |
---|---|---|
Higher Affinity than WT | ||
L74P | LOW | Q226 |
L75P | LOW | Y98 |
E119G | LOW | Y98, T136 |
P128S | LOW | G134, T136 |
N129K | LOW | H183, T155, W153 |
G143R | LOW | Y98, T136 |
E156G | LOW | Y98, W153, T155, H183 |
E156K | LOW | Y98, W153, T155, H183 |
E158V | LOW | W153, T155 |
L164Q | LOW | W153, H183, Y98, Q226 |
K165E | LOW | H183, E190 |
N166K | LOW | H183, L194 |
Q192R | LOW | W153, T155 |
N193K | LOW | T136 |
Q196R | LOW | T155, W153, H183, Y98, Q226 |
E198G | LOW | H183, L194 |
R224I | LOW | Y98, W153, H183, Q226 |
I244T | LOW | H183, L194 |
Lower Affinity than WT | ||
I93T | LOW | Y98, T136, W153, H183, Q226 |
S145G | LOW | Y98 |
S145N | LOW | Y98, T136 |
N193S | LOW | W153 |
Similar Affinity as WT | ||
V77E | LOW | _ |
R78G | LOW | _ |
S79P | LOW | _ |
E119K | LOW | Y98, T136 |
N129Y | LOW | H183, T155, W153 |
S140P | LOW | _ |
G159D | LOW | _ |
S160L | LOW | W153, H183 |
K163T | LOW | W153, H183 |
S167Y | LOW | _ |
S167F | LOW | _ |
V169A | LOW | _ |
G173E | LOW | _ |
G173R | LOW | _ |
Q192L | LOW | W153, T155 |
G240E | LOW | _ |
G240R | LOW | _ |