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. 2011 Dec 19;1:200. doi: 10.1038/srep00200

Table 1. Link between mutations in antigenic site and RBS residues for HA-escape mutants10. SA-anchoring RBS residues contained within the SIN of antigenic residues whose SIN score is generally higher than corresponding score in wild-type HA as a result of antigenic mutations that increase glycan-binding affinity are highlighted in yellow. Highlighted in cyan are SA-anchoring residues contained within the SIN of antigenic residues whose SIN score is generally lower than corresponding score in wild-type HA as a result of antigenic mutations that decrease glycan-binding affinity. In the case of mutations that do not alter the glycan-binding affinity, most of these residues do not have any SA-anchoring RBS residues in their SIN. The SA-anchoring RBS residues (whose SIN scores are not affected) are in the network of these antigenic mutations are shown in red text.

Emergent Mutation SIN Score RBS Residues in SIN
Higher Affinity than WT
L74P LOW Q226
L75P LOW Y98
E119G LOW Y98, T136
P128S LOW G134, T136
N129K LOW H183, T155, W153
G143R LOW Y98, T136
E156G LOW Y98, W153, T155, H183
E156K LOW Y98, W153, T155, H183
E158V LOW W153, T155
L164Q LOW W153, H183, Y98, Q226
K165E LOW H183, E190
N166K LOW H183, L194
Q192R LOW W153, T155
N193K LOW T136
Q196R LOW T155, W153, H183, Y98, Q226
E198G LOW H183, L194
R224I LOW Y98, W153, H183, Q226
I244T LOW H183, L194
Lower Affinity than WT
I93T LOW Y98, T136, W153, H183, Q226
S145G LOW Y98
S145N LOW Y98, T136
N193S LOW W153
Similar Affinity as WT
V77E LOW _
R78G LOW _
S79P LOW _
E119K LOW Y98, T136
N129Y LOW H183, T155, W153
S140P LOW _
G159D LOW _
S160L LOW W153, H183
K163T LOW W153, H183
S167Y LOW _
S167F LOW _
V169A LOW _
G173E LOW _
G173R LOW _
Q192L LOW W153, T155
G240E LOW _
G240R LOW _