Table 1.
Data set (N cases/N controls) | Control frequency |
OR
(95% CI) |
P-value |
---|---|---|---|
Initial set (2280/16 099) | 0.58 | 1.09 (1.01, 1.18) | 0.037 |
Follow-up (2797/4407) | 0.59 | 1.08 (1.01, 1.16) | 0.033 |
Initial set and follow-up (5077/20 506) | 0.59 | 1.08 (1.03, 1.14) | 0.0029 |
Abbreviations: CI, confidence interval; OR, odds ratio.
Control frequency is the average, unweighted allele frequency over the various study groups of each data set, whereas ORs and P-values were estimated using the Mantel–Haenszel model. Analysis for each genome-wide typed group was adjusted using genomic control (see Materials and methods).