Table 1.

ABT-737 sensitises neuroblastoma cell lines to conventional cytotoxics agents in both normoxia and hypoxia. Combination index (CI) values are shown for the combination of ABT-737, at its IC50 dose in normoxia and hypoxia, and vincristine, cisplatin, etoposide and doxorubicin in 4 neuroblastoma cell lines. CI values of 1 indicate additivity, values below 1 indicate synergy; the lower the value the greater the synergy.

Cell line	Combination with ABT-737	IC50 normoxia	IC50 hypoxia
SH-EP1	etoposide	0.79333	0.36945
SH-EP1	doxorubicin	0.8162	0.88215
SH-EP1	cisplatin	0.55949	0.66894
SH-EP1	vincristine	1.06206	0.60202
SH-SY5Y	etoposide	0.38021	0.14637
SH-SY5Y	doxorubicin	0.51517	0.17208
SH-SY5Y	cisplatin	0.90007	0.20182
SH-SY5Y	vincristine	1.22763	0.52357
LA1-5s	etoposide	0.122	0.27131
LA1-5s	doxorubicin	0.6305	0.76332
LA1-5s	cisplatin	1.04588	0.61367
LA1-5s	vincristine	0.73087	0.69199
LA1-55n	etoposide	0.90738	0.81952
LA1-55n	doxorubicin	0.99311	0.51199
LA1-55n	cisplatin	0.89014	0.86183
LA1-55n	vincristine	1.246	0.91284