Table 2.
Behavioural measures in the open field in mice treated with vehicle or the steroid sulfatase inhibitor COUMATE.
| Test and measure | Vehicle-treated (n = 12) | COUMATE-treated (n = 12) | Significance level |
|---|---|---|---|
| Open field | |||
| Latency to enter inner zone (s) | 37.3 ± 7.2 | 43.7 ± 14.2 | t[22] = −0.40, p = 0.69 |
| Time spent in outer zone (s) | 224.3 ± 7.4 | 234.9 ± 6.8 | t[22] = −1.06, p = 0.30 |
| Transitions between quadrants | 45.9 ± 3.4 | 41.1 ± 4.4 | t[22] = 0.87, p = 0.39 |
| Rears | 40.8 ± 3.4 | 29.8 ± 3.5 | t[22] = 2.29, p < 0.05 |
| Fecal boli deposited | 1.7 ± 0.5 | 2.1 ± 0.5 | U = 62.5, p = 0.59 |
| Mice urinating/mice not urinating | 2/10 | 2/10 | Fisher Exact Test, p = 1.0 |