Table 1.
Potential hepatic REHs and their orthologs in mouse, rat, and humans.
| Species | Protein | Gene | Alternative gene names | Localization | Tissues |
|---|---|---|---|---|---|
| Mouse | Es1 | Ces1c | Ee1, Es4, EsN, Ee-1, Es-4, Es-N, PESN, Ces-N | ER extracellular [186] | liver (kidney, testis, lung) [187,188] |
| Rat | Es2 | Ces1c | Es1, Es2, pI 6.1 esterase, NREH serum/liver carboxylesterase 1 | ER (lumen) extracellular [86] | liver [82] |
| Human | CES1 | CES1 | TGH, ACAT, CEH, CES2, HMSE, SES1, HMSE1, PCE-1, MGC117365 | ER (lumen) [189] | liver, lung (others) [190–193] |
| Mouse | Es22 | Ces1e | Eg, egasyn | ER [87] | liver (adipose, kidney) [87] |
| Rat | Es3 | Ces1e | Ces1, Es22, pI 5.6 esterase, MGC156521 | ER (lumen) [86] | liver, kidney, intestine [92] |
| Human | CES1 | CES1 | as above | ||
| Mouse | Ces1f | Ces1fa | TGH-2, CesML1, AU018778, MGC18894 | ER, cytosol, lipid droplet [194] | liver, intestine, kidney, adipose [194] |
| Rat | Es4 | Ces1f | Carboxylesterase pI 6.2/6.4, liver carboxylesterase Es4, | ER [78] | liver, kidney [92] |
| Human | CES1 | CES1a | as above | ||
| Mouse | Ces1d | Ces1d | CES3, TGH, FAEE synthase | ER, cytosol, lipid droplet [194,195] | liver, kidney, heart, adipose [86] |
| Rat | Es10 | Ces1d | Carboxylesterase pI 6.0/6.1, Ces3, ES-HVEL, FAEE synthase | ER (lumen) [86] | liver (lung, testis) [84] |
| Human | CES1 | CES1 | as above |
a
Genes of highest sequence similarity, orthologs not yet specified.