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. 2011 Sep 7;37(2):422–433. doi: 10.1038/npp.2011.189

Figure 2.

Figure 2

Temporal profiles of mBDNF levels in the hippocampus after the passive avoidance training or bicuculline methiodide (BMI) administration. a, To determine the temporal profile of mBDNF levels after the acquisition trial without any drug administration, mice were subjected to the one-trial passive avoidance task (0.25 mA, 3 s) and then sacrificed (†) at designated time points [immediately (0), 0.5, 1, 3, 6, 9, or 12 h] after the acquisition trial for the western blotting. Naïve mouse group (N) did not received any administration of drug or training. Data are presented as means±SEM (n=4/group). *P<0.05, compared to the normal group (one-way ANOVA followed by Tukey's post hoc test). b, To investigate the temporal profiles of mBDNF levels after BMI administration, mice were treated with BMI (5 mg/kg, i.p.) and sacrificed (†) at designated time points [immediately (0), 1, 3, 6, 9, 12, or 24 h] after the administration for western blotting. Data are presented as means±SEM (n=3/group). *P<0.05, compared with the 0 h group (one-way ANOVA followed by Tukey's post hoc test).