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. 2011 Sep 7;37(2):434–444. doi: 10.1038/npp.2011.191

Figure 2.

Figure 2

Effects of systemic 7,8-DHF on memory deficits in 5XFAD mice. 5XFAD and wild-type control mice at 12–15 months of age received repeated administration of 7,8-DHF (5 mg/kg, i.p.) or vehicle (17% DMSO) once daily for 10 consecutive days. Two hours after the last injection, the mice were tested for memory using the spontaneous alternation Y-maze task. (a) Spatial working memory, as assessed by the spontaneous alternation performance, is impaired (around 50% chance levels) in 5XFAD mice compared with wild-type controls (*p<0.05). Note that 7,8-DHF-treated 5XFAD mice are rescued completely back to wild-type levels of alternation performance (#p<0.05 vs vehicle-treated 5XFAD). n=5–12 mice per group. (b) Total number of arm entries reflecting exploratory activities of mice in the Y-maze does not differ between the groups, suggesting that the effect of 7,8-DHF is memory-specific. n=5–12 mice per group. All data are presented as mean±SEM.