Table 4. Contrast Between Fearful and Neutral Faces in Each Condition.

Region	t-score	No of voxels	x	y	Z	Peak p value
SDs: placebo
R parahippocampal gyrus/caudate/amygdala	5.38	735	37	−19	−12	<0.0001
Bilateral medial frontal gyrus	6.41	420	19	67	4	<0.0001
L lingual gyrus	5.34	395	−25	−83	−2	<0.0001
R lingual gyrus	4.63	222	21	−85	0	<0.0001
L parahippocampal gyrus/amygdala	5.66	206	−29	−7	−12	<0.0001
L inferior parietal lobule	6.71	188	−43	−45	44	<0.0001
R medial frontal gyrus	6.02	184	9	47	36	<0.0001
L cingulate gyrus	4.06	95	−3	−27	34	<0.0001
L precuneus	−4.47	67	−11	−59	50	<0.0001
R superior frontal gyrus	4.37	66	17	17	54	<0.0001
R middle frontal gyrus	6.29	62	31	43	−14	<0.0001
L superior frontal gyrus	−4.76	61	−15	−7	66	<0.0001
R caudate	4.28	56	7	−1	14	<0.0001
L superior frontal gyrus	5.11	45	−27	59	4	<0.0001
SDs: alcohol
L parahippocampal gyrus	−4.0	50	−23	−43	−4	<0.0001
HDs: placebo
R middle temporal gyrus	5.87	176	53	−53	8	<0.0001
R posterior cingulate	3.86	65	29	−65	12	<0.001
HDs: alcohol
R lingual gyrus	6.45	348	21	−89	4	<0.0001
L middle frontal gyrus	4.83	92	−43	49	8	<0.001
R middle frontal gyrus	4.52	47	51	43	14	<0.001

Activations are thresholded at p<0.01, with a cluster size k⩾40 voxels, yielding a corrected p value of 0.05. Positive t-values indicate greater activation to fearful than neutral faces; negative t values indicate greater activation to neutral than to fearful faces. Coordinates refer to the Talairach system.