Table 2. P-Values for Associations and Cis-Acting Regulatory Effects of the SNPs in TNN–KIAA0040 Region.
| SNP | A1 | EA | AA | P-values for eQTL in six HapMap populations | P-values for eQTL in Europeansa | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | P-value | OR | P-value | CEU_children | CEU_parent | CHB | JPT | YRI_children | YRI_parent | Transcript (B) | Exon 1 (P) | Exon 4 (P) | ||
| rs12094153 | A | 1.210 | 3.9 × 10−4 | — | — | — | — | — | — | — | — | — | 2.8 × 10−3 | — |
| rs4651322 | T | 0.889 | 0.034 | — | — | — | — | — | 6.0 × 10−3 | — | — | — | — | — |
| rs2157588 | A | 1.219 | 1.9 × 10−4 | — | — | — | — | — | — | — | — | — | — | — |
| rs12563833 | A | 0.893 | 0.047 | — | — | — | — | — | 0.023 | — | — | — | — | — |
| rs1018829 | T | 0.839 | 6.8 × 10−3 | — | — | — | — | — | 0.035 | — | — | — | — | — |
| rs10489328 | A | 0.848 | 0.017 | — | — | — | — | — | — | — | — | 0.023 | — | — |
| rs2018318 | T | 0.836 | 9.9 × 10−3 | — | — | — | — | — | — | — | — | — | — | — |
| rs6701037 | C | 1.295 | 1.3 × 10−6 | — | — | — | — | — | 0.025 | 0.037 | 6.0 × 10−4 | — | 9.4 × 10−4 | — |
| rs10912899 | A | 0.871 | 9.4 × 10−3 | — | — | — | — | — | — | — | 0.014 | — | — | 3.2 × 10−4 |
| rs4650707 | A | 0.741 | 0.024 | — | — | — | — | — | — | — | — | — | — | — |
| rs6425323 | T | 1.291 | 1.9 × 10−6 | — | — | 0.010 | 8.9 × 10−3 | — | 0.025 | 0.038 | 5.0 × 10−4 | — | — | — |
| rs1057302 | C | 1.286 | 2.5 × 10−6 | — | — | 0.013 | 4.8 × 10−3 | — | 0.025 | — | 2.0 × 10−4 | — | — | — |
| rs3737933 | C | 0.850 | 0.023 | 1.757 | 0.040 | 4.0 × 10−3 | 4.0 × 10−3 | 0.024 | 0.035 | — | — | — | — | — |
| rs1057285 | G | — | — | 1.412 | 5.1 × 10−4 | 1.4 × 10−3 | 0.014 | — | — | — | — | — | — | — |
| rs4650716 | C | 1.249 | 2.2 × 10−5 | — | — | — | — | — | — | 0.025 | — | — | — | — |
| rs2269650 | A | 0.842 | 1.4 × 10−3 | — | — | — | — | — | — | — | — | — | — | 8.6 × 10−5 |
| rs2072035 | A | 0.841 | 1.3 × 10−3 | — | — | — | — | — | — | — | — | — | — | — |
| rs1057239 | T | 1.318 | 2.8 × 10−7 | — | — | — | 0.028 | — | — | 0.011 | — | — | — | — |
| rs1894709 | A | 1.313 | 3.9 × 10−7 | — | — | — | 8.0 × 10−3 | — | — | 0.016 | — | — | — | — |
| rs10489326 | T | 1.242 | 3.4 × 10−5 | — | — | — | — | — | — | 0.021 | — | — | — | — |
| rs2269655 | T | — | — | 1.875 | 0.026 | 0.020 | 0.039 | 0.031 | — | — | — | 6.9 × 10−3 | — | — |
| rs2861158 | A | 0.863 | 0.011 | — | — | — | — | — | — | — | — | — | — | — |
| rs16847872 | G | — | — | 1.872 | 0.026 | 0.020 | 0.039 | 0.031 | — | — | — | — | — | — |
| rs12136973 | C | 0.865 | 0.012 | — | — | — | — | — | 0.040 | — | — | — | — | 2.5 × 10−3 |
| rs1008459 | G | 0.881 | 0.029 | — | — | — | — | 0.018 | 0.028 | — | — | — | — | 1.1 × 10−3 |
| rs2272785 | A | 0.879 | 0.025 | — | — | — | — | 0.018 | 0.044 | — | — | — | — | — |
| rs2272784 | C | 0.823 | 2.8 × 10−4 | — | — | — | — | — | — | — | — | — | — | 7.7 × 10−6 |
| rs3753555 | C | 0.823 | 2.8 × 10−4 | — | — | — | — | — | — | — | — | — | — | 7.7 × 10−6 |
Abbreviations: eQTL, expression quantitative trait locus analysis.
a
Exon-level expression changes in brain (B) and PBMC (P) tissues were corrected for 4 exons and 2 tissues (α=0.0063).
‘—', p>0.05 or not available.
All markers are in HWE.