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. Author manuscript; available in PMC: 2011 Dec 19.
Published in final edited form as: J Am Chem Soc. 2007 Jun 13;129(26):8068–8069. doi: 10.1021/ja072013j

Scheme 1.

Scheme 1

a Conditions: (a) N-methylmorpholine, isobutyl chloroformate, N,O-dimethylhydroxylamine, CH2Cl2, 2 h, 99%; (b) Me–MgBr, toluene, 3 h, 67%; (c) (i) NH3, hydroxylamine-O-sulfonic acid, (ii) TEA, I2, MeOH, 49%; (d) 4 M HCl, THF, 20 h, 99%; (e) NaHCO3, Fmoc-OSu, 1,4-dioxane, 20 h, 97%.