Table 1.
Genotype distribution and allele frequencies for 5-HTTLPR in the San Diego database and Coriell controls
| SIDS |
||||||
|---|---|---|---|---|---|---|
| 5HTTLPR | Total | Caucasian | African American |
Hispanic | Asian | Mixed |
| Genotype | ||||||
| SS | 42 (23.46) | 14 (14.89) | 4 (21.05) | 18 (39.13) | 3 (42.86) | 3 (23.08) |
| SL | 83 (46.37) | 51 (54.26) | 6 (31.58) | 18 (39.13) | 3 (42.86) | 5 (38.46) |
| LL | 54 (30.17) | 29 (30.85) | 9 (47.37) | 10 (21.74) | 1 (14.29) | 5 (38.46) |
| SXL | ||||||
| LXL | ||||||
| Allele | ||||||
| S | 167 (46.65) | 79 (42.02) | 14 (36.84) | 54 (58.70) | 9 (64.29) | 11 (42.31) |
| L | 191 (53.35) | 109 (57.98) | 24 (63.16) | 38 (41.30) | 5 (35.71) | 15 (57.69) |
| XL | ||||||
| Controls |
||||||
|---|---|---|---|---|---|---|
| 5HTTLPR | Total | Caucasian | African American |
Hispanic | Asian | Mixed |
| Genotype | ||||||
| SS | 28 (20.14) | 20 (20.00) | 0 (0.00) | 4 (17.39) | 3 (50.00) | 1 (33.33) |
| SL | 73 (52.52) | 53 (53.00) | 5 (71.43) | 12 (52.17) | 1 (16.67) | 2 (66.67) |
| LL | 38 (27.34) | 27 (27.00) | 2 (28.57) | 7 (30.43) | 2 (33.33) | 0 (0.00) |
| SXL | ||||||
| LXL | ||||||
| Allele | ||||||
| S | 129 (46.40) | 93 (46.50) | 5 (35.71) | 20 (43.48) | 7 (58.33) | 4 (33.33) |
| L | 149 (53.60) | 107 (53.50) | 9 (64.29) | 26 (56.52) | 5 (41.67) | 2 (66.67) |
| XL | ||||||
| Coriell |
|||
|---|---|---|---|
| 5HTTLPR | Caucasian | African American |
Hispanic |
| Genotype | |||
| SS | 20 (20.00) | 11 (11.20) | 37 (37.00) |
| SL | 48 (48.00) | 48 (48.00) | 43 (43.00) |
| LL | 32 (32.00) | 38 (38.80) | 23 (23.00) |
| SXL | 1 (1.00) | ||
| LXL | 1 (1.00) | ||
| Allele | |||
| S | 88 (44.00) | 69 (35.20) | 114 (57.00) |
| L | 112 (56.00) | 123 (62.80) | 86 (43.00) |
| XL | 0 (0.00) | 2 (1.00) | |
The data represent number of cases/controls and percentage for each genotype and allele. No significant differences in genotype distribution or allele frequency were observed between SIDS cases and controls either in the total cohort or when each ethnicity was analyzed separately with or without the addition of the Coriell controls.