Table 3.
Dataset/study |
||||||
---|---|---|---|---|---|---|
Coriell | Weese-Mayer et al. (18) | Nonnis Marzano et al. (15) | Opdal et al. (16) | Haas et al. (19) | San Diego | |
Allele | ||||||
S | 88 (44.0) | 49 (53.3) | 172 (57.7) | 227 (46.5) | 48 (41.1) | 93 (46.5) |
L | 112 (56.0) | 43 (46.7) | 128 (42.7) | 261 (53.5) | 68 (58.6) | 107 (53.5) |
Fisher’s exact test | 0.16 | 0.005* | 0.56 | 0.72 | 0.69 | |
HWE | 0.08 | 0.04* | 0.90 | 0.59 | 0.69 |
The data represent the number of Caucasian controls and percentage of each allele in each dataset/study.
Allele frequency of the controls in the study by Nonnis Marzano et al. (15) was significantly different from the allele frequency in the Coriell control panel. Allele frequency in this population was also out of Hardy-Weinberg Equilibrium (HWE).