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. 2011 Dec 14;441(Pt 1):317–323. doi: 10.1042/BJ20111617

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© 2012 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.

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Top panel: schematic illustration of the TPC showing the two hydrophobic domains (I and II) each comprising six TM regions (numbered in domain I) and a pore (P). The domains are connected by a cytosolic loop. A summary of the constructs used in the present study encoding the indicated region, together with the predicted size of the Myc- and/or GFP-fusion proteins are listed in the bottom part of the Figure. Constructs correspond to human (TPC1 and TPC2) or sea urchin (SpTPC1–3) isoforms.