Table 1. Expression (MFI) of HER family members (EGFR, HER-2, HER-3 and HER-4) in human pancreatic cancer cell lines.
|
Mean fluorescence intensity (MFI)
|
|||||
|---|---|---|---|---|---|
| Cell line | Control | EGFR | HER-2 | HER-3 | HER-4 |
| Capan-1 | 4.2±0.7 | 138.5±15.2 | 28.9±3.1 | 7.4±0.7 | 4.9±0.4 |
| PT-45 | 2.9±0.6 | 184.7±21.1 | 21±1.9 | 6.1±0.4 | 3.9±0.3 |
| PANC-1 | 3±0.2 | 119.7±7.6 | 13.6±0.6 | 3.4±0.1 | 4.1±0.2 |
| BxPC-3 | 8±1.2 | 98.0±12.7 | 29.4±3.3 | 15.5±1.5 | 9.8±0.5 |
| MiaPaCa-2 | 3.7±0.3 | 39.5±3 | 32.9±3.8 | 4±0.3 | 4.4±0.3 |
| AsPc-1 | 3.6±0.7 | 97.4±12.8 | 19±2 | 5.9±0.5 | 4.1±1.3 |
| FA6 | 5.9±0.4 | 40.4±8.2 | 14.5±1.9 | 9.8±1.4 | 5.5±0.5 |
| SKBR3 (breast) | 4.3±0.2 | N/A | 831.3±74.6 | 21.2±8.7 | N/A |
| MDA-MB468 (breast) | 3.8±0.3 | 415.3±42 | N/A | N/A | N/A |
| MCF-7 (breast) | 3.5±0.3 | N/A | N/A | N/A | 24.6±2.3 |
Abbreviation: EGFR=epidermal growth factor receptor.
Breast cancer cell lines SKBR3, MDA-MB468 and MCF-7 were used as positive controls for HER-2/HER-3, EGFR and HER-4 receptors, respectively.