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. 2011 Oct 11;105(10):1582–1592. doi: 10.1038/bjc.2011.403

Figure 3.

Figure 3

Representative sections of dysplastic oral mucosa taken from patient biopsies (DOM) (AE) and tissue-engineered dysplastic oral mucosa constructs (TEDOM) (FJ). TEDOM models were generated by culturing D20 or Cal27 cells and normal oral fibroblasts on DED at an air-to-liquid interface for 14 days. Sections were stained with H&E (A, F and K) and immunohistochemically stained to show the pattern of expression of Ki67 (B, G and L), AE1/3 (C, H and M), collagen type IV (Col IV; D, I and N) and integrin αvβ6 (E, J and O) and counterstained with haematoxylin. Scale bar indicates 200 μm.