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. 2011 Nov 8;105(10):1608–1614. doi: 10.1038/bjc.2011.432

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Copyright © 2011 Cancer Research UK

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Downregulation of TMPRSS4 results in a decrease in lung tumour growth. (A) Representative luminometric images of mice injected with 5 × 10⁵ H358 control or shTMP4 cell clones in the tail vein. Photon emission quantification revealed a significant reduction in tumour growth in the groups injected with shTMP4-2 and shTMP4-3 cell clones (P<0.05). (B) Representative histological images of lungs from mice injected with H358 shCtrl (a, b) or shTMP4-2 (c, d) cell clones. Large tumours with highly angiogenic and haemorrhagic areas could be seen in control mice, but not in the shTMP4 group. Bars: a, c: 300 μm; b, d: 120 μm. ^*P<0.05.