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. 2011 Nov 1;105(11):1708–1718. doi: 10.1038/bjc.2011.445

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Copyright © 2011 Cancer Research UK

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Bortezomib treatment of engrafted fresh human multiple myeloma (MM) in turkey embryos. (A) Flow cytometry detection of human MM cell engraftment into turkey embryo bone marrow (BM) and of bortezomib-treated embryo on embryonic day 13 (E13). Bone marrow from turkey embryos was collected on E18 and cells stained with fluorescein isothiocyanate (FITC) anti-human CD138 and APC anti-human CD19. Human cells were detected in the samples from injected embryos, but not in non-injected embryos. (B) Quantitative real-time polymerase chain reaction (Q-PCR) of human alpha satellite DNA also detected human cellular DNA in the turkey embryo haematopoietic organs. Human cells were detected in the samples from MM patient-injected embryos, but not in those treated by bortezomib. ^*P⩽0.002 relative to MM patient-injected embryos.