Table 4. Survival of embryos after treatment with varying concentrations of thalidomide.
Thalidomide concentration | Number of turkey embryos injected on E13 | Number of turkey embryos that survived by E18 |
---|---|---|
0 (vehicle only 50% PBS+50% ethanol) | 6 | 5 |
30 μg per embryo | 6 | 0 |
60 μg per embryo | 6 | 0 |
120 μg per embryo | 6 | 0 |
0 (vehicle only 50% PBS+50% ethanol) | 6 | 4 |
3 μg per embryo | 6 | 0 |
6 μg per embryo | 6 | 0 |
12 μg per embryo | 6 | 0 |
0 (vehicle only 50% PBS+50% ethanol) | 6 | 5 |
0.3 μg per embryo | 6 | 0 |
0.6 μg per embryo | 6 | 0 |
0.12 μg per embryo | 6 | 0 |
Abbreviation: PBS=phosphate-buffered solution.
The human therapeutic dose is equivalent to 60–120 μg per embryo.