Table 6. Survival of embryos after treatment with increasing concentrations of lenalinomide.

Lenalinomide dose	Survival (%)	Number of embryos treated	Number of embryos that survived
0 (only 70% ethanol+30% PBS)	100	6	6
7.5 μg per embryo	83	6	5
15 μg per embryo	100	6	6
30 μg per embryo	83	6	5
0 (only 70% ethanol+30% PBS)	83	6	5
30 μg per embryo	100	6	6
60 μg per embryo	66	6	4
120 μg per embryo	83	6	5

Abbreviations: BM=bone marrow; PBS=phosphate-buffered solution.

The human therapeutic dose is equivalent to 15 μg per embryo. Doses of up to 120 μg per embryo were not lethal or toxic to the BM.