Table 2. Ranking of the pigmentation-related genes included in the 278 probe set signature associated with a poorer survival.
| Ranka | P-valueb | FDR | Geom. mean of intensities in OS <30 months | Geom. mean of intensities in OS >30 months | Fold change | Probe set | Gene symbol | Description |
|---|---|---|---|---|---|---|---|---|
| 1 | 0.00004 | 0.15 | 687.4 | 20.3 | 33.9 | 205694_at | TYRP1 | Tyrosinase-related protein 1 |
| 2 | 0.00040 | 0.19 | 3077.2 | 186.7 | 16.5 | 209848_s_at | SILV | Silver homolog (mouse) |
| 4 | 0.00103 | 0.20 | 1291.6 | 97.0 | 13.3 | 205338_s_at | DCT | Dopachrome tautomerase (tyrosine-related protein 2) |
| 13 | 0.00174 | 0.21 | 145.3 | 18.0 | 8.1 | 206498_at | OCA2 | Oculocutaneous albinism II |
| 15 | 0.02823 | 0.33 | 3170.1 | 496.5 | 6.4 | 206630_at | TYR | Tyrosinase (oculo-cutaneous albinism IA) |
| 99 | 0.02147 | 0.32 | 1054.3 | 375.4 | 2.8 | 207233_s_at | MITF | Microphthalmia-associated transcription factor |
| Controlc | 0.649 | — | 929.0 | 1145.2 | 0.8 | 209686_at | S100B | S100 calcium binding protein B |
Abbreviations: Geom=geometric; FDR=false discovery rate; OS=overall survival.
a
Position in the complete list (278 probe sets).
b
Two-sample t-test.
c
Assessed as control for difference in tumour load.