Table 2. Statistics of main effect quantitative trait loci detected in genome wide scan in the full data set.
MMU | Traits | Peak (cM)a |
Flanking markersb |
Estimate |
%var | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Left | Right | F | LOD | a | s.ea | d | s.ed | ||||
1 | ADG35–42** | 22 | rs3696088 | rs13472794 | 15.83 | 6.766 | −0.107 | 0.020 | −0.027 | 0.026 | 3.11 |
1 | ADG28–42** | 23 | rs3696088 | rs13472794 | 25.91 | 10.968 | −0.108 | 0.015 | −0.027 | 0.021 | 4.99 |
1 | ADG28–35** | 24 | rs3696088 | rs13472794 | 10.63 | 4.568 | −0.110 | 0.024 | −0.027 | 0.032 | 2.11 |
2 | ADG14–21** | 71 | rs3144393 | rs13476878 | 26.27 | 11.115 | 0.061 | 0.009 | 0.028 | 0.012 | 5.05 |
2 | ADG7–21** | 79 | rs3144393 | rs13476878 | 15.18 | 6.491 | 0.024 | 0.006 | 0.035 | 0.009 | 2.98 |
2 | BW28** | 79 | rs3144393 | rs13476878 | 11.88 | 5.096 | 0.548 | 0.187 | 1.082 | 0.276 | 2.35 |
2 | BW21** | 81 | rs3144393 | rs13476878 | 14.21 | 6.083 | 0.427 | 0.118 | 0.708 | 0.179 | 2.80 |
2 | ADG7–14 | 96 | rs13476878 | rs3143843 | 8.13 | 3.500 | −0.018 | 0.006 | 0.024 | 0.009 | 1.62 |
2 | BW14** | 101 | rs13476878 | rs3143843 | 10.27 | 4.414 | −0.032 | 0.064 | 0.400 | 0.089 | 2.04 |
2 | BW7** | 103 | rs3143843 | rs6335805 | 10.46 | 4.497 | 0.077 | 0.044 | 0.269 | 0.063 | 2.08 |
3 | ADG28–35** | 25 | rs3663409 | rs13477132 | 13.32 | 5.708 | 0.040 | 0.013 | 0.075 | 0.019 | 2.63 |
3 | ADG28–42 | 30 | rs3663409 | rs13477132 | 10.55 | 4.534 | 0.027 | 0.009 | 0.045 | 0.013 | 2.09 |
3 | ADG7–42** | 58 | rs3663873 | rs13477430 | 12.94 | 5.546 | 0.027 | 0.006 | 0.026 | 0.009 | 2.55 |
3 | BW42** | 61 | rs3663873 | rs13477430 | 10.78 | 4.632 | 0.988 | 0.239 | 1.011 | 0.405 | 2.14 |
3 | BW35 | 64 | rs3663873 | rs13477430 | 8.95 | 3.851 | 0.999 | 0.246 | 0.713 | 0.438 | 1.78 |
3 | ADG21–28 | 120 | rs3724562 | CEL–3_159340478 | 8.85 | 3.811 | 0.057 | 0.014 | −0.011 | 0.027 | 1.76 |
4 | ADG7–21** | 63 | rs6324470 | rs3659226 | 10.15 | 4.363 | −0.023 | 0.006 | 0.015 | 0.008 | 2.02 |
4 | BW21 | 64 | rs6324470 | rs3659226 | 7.95 | 3.426 | −0.400 | 0.110 | 0.262 | 0.169 | 1.59 |
4 | BW28** | 64 | rs6324470 | rs3659226 | 10.64 | 4.572 | −0.738 | 0.175 | 0.486 | 0.269 | 2.11 |
4 | BW35 | 67 | rs6324470 | rs3659226 | 8.08 | 3.480 | −0.733 | 0.212 | 0.667 | 0.342 | 1.61 |
5 | ADG7–42 | 76 | rs3720626 | rs3706737 | 8.52 | 3.669 | 0.020 | 0.005 | −0.007 | 0.007 | 1.70 |
5 | ADG28–42 | 78 | rs3720626 | rs3706737 | 8.94 | 3.850 | 0.029 | 0.008 | −0.020 | 0.012 | 1.78 |
6 | ADG7–21 | 23 | rs13478727 | rs13478839 | 8.11 | 3.495 | 0.019 | 0.006 | 0.021 | 0.009 | 1.62 |
6 | BW28** | 27 | rs13478727 | rs13478839 | 14.07 | 6.026 | 0.885 | 0.177 | 0.544 | 0.268 | 2.77 |
6 | BW35** | 27 | rs13478727 | rs13478839 | 16.54 | 7.064 | 1.157 | 0.203 | 0.316 | 0.307 | 3.24 |
6 | BW42** | 28 | rs13478727 | rs13478839 | 15.88 | 6.789 | 1.124 | 0.203 | 0.428 | 0.304 | 3.12 |
6 | ADG7–42** | 29 | rs13478727 | rs13478839 | 16.40 | 7.009 | 0.030 | 0.005 | 0.010 | 0.008 | 3.22 |
6 | ADG21–28** | 30 | rs13478727 | rs13478839 | 16.65 | 7.112 | 0.076 | 0.013 | 0.026 | 0.019 | 3.26 |
10 | ADG7–14** | 32 | CEL-10_58149652 | rs13480647 | 10.82 | 4.647 | −0.026 | 0.006 | −0.020 | 0.010 | 2.14 |
10 | ADG28–42 | 32 | CEL-10_58149653 | rs13480648 | 10.65 | 4.578 | 0.038 | 0.008 | −0.007 | 0.013 | 2.11 |
10 | ADG28–35 | 36 | CEL-10_58149654 | rs13480649 | 8.77 | 3.777 | 0.056 | 0.013 | −0.010 | 0.021 | 1.75 |
10 | BW42 | 37 | CEL-10_58149655 | rs13480650 | 9.08 | 3.907 | 0.864 | 0.207 | −0.270 | 0.319 | 1.81 |
10 | ADG21–28 | 44 | rs3717445 | rs13480707 | 8.39 | 3.611 | 0.053 | 0.013 | −0.016 | 0.019 | 1.67 |
10 | ADG7–42** | 47 | rs13480707 | rs13480754 | 10.05 | 4.322 | 0.023 | 0.005 | −0.008 | 0.008 | 2.00 |
11 | ADG21–28** | 26 | rs6276300 | rs6199956 | 17.78 | 7.584 | 0.073 | 0.014 | 0.053 | 0.022 | 3.48 |
11 | ADG7–42** | 28 | rs6276300 | rs6199956 | 20.51 | 8.726 | 0.034 | 0.006 | 0.012 | 0.009 | 3.99 |
11 | BW42** | 28 | rs6276300 | rs6199956 | 18.86 | 8.038 | 1.258 | 0.215 | 0.439 | 0.335 | 3.68 |
11 | BW28** | 29 | rs6276300 | rs6199956 | 13.66 | 5.851 | 0.873 | 0.187 | 0.563 | 0.291 | 2.69 |
11 | BW35** | 29 | rs6276300 | rs6199956 | 17.53 | 7.482 | 1.176 | 0.214 | 0.573 | 0.333 | 3.43 |
12 | ADG7–14 | 61 | rs6288403 | rs6390948 | 8.91 | 3.836 | −0.022 | 0.006 | 0.016 | 0.008 | 1.77 |
18 | ADG7–42 | 8 | rs13483233 | rs3723947 | 8.53 | 3.673 | 0.021 | 0.005 | 0.002 | 0.007 | 1.70 |
18 | BW35 | 8 | rs13483233 | rs3723947 | 9.15 | 3.938 | 0.819 | 0.192 | 0.042 | 0.272 | 1.82 |
18 | BW42 | 8 | rs13483233 | rs3723947 | 8.61 | 3.707 | 0.802 | 0.193 | 0.043 | 0.275 | 1.71 |
18 | ADG14–21 | 36 | rs3670254 | rs3718618 | 8.59 | 3.698 | 0.038 | 0.009 | −0.001 | 0.014 | 1.71 |
Abbreviations: a, additive effect; d, dominance effect; MMU, mouse chromosome; s.ea, standard error of additive effect; s.ed, standard error of dominance effect; %var, percentage of phenotypic variance accounted for by quantitative trait loci.
Peak position of quantitative trait loci detected in Kosambi centimorgans.
Flanking markers (left and right) of the quantitative trait loci peak.
**Quantitative trait loci with an F-value that exceeded the 1% genome-wide permutation threshold.
Other quantitative trait loci exceeded the 5% threshold.
A positive estimate indicates that the effect of the recurrent quantitative trait loci genotype is larger than the effect of the heterozygous genotype.