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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Eur J Med Chem. 2011 May 30;46(9):3832–3844. doi: 10.1016/j.ejmech.2011.05.051

Scheme 2.

Scheme 2

Transglycosylation to l-3-azido purines starting from LdT. Reagents and conditions: (a) 1 eq LdT, 1.02 eq TBSCl, pyridine, CH2Cl2, rt, 18 h, 92%; (b) DIAD, tpp, tol, 80 °C, 30 min, 79%; (c) LiN3, dmf, 130 °C, 2 days, 67%; (d) BSA, TMSOTf, acetonitrile, 85 °c, 18 h, 81%; (e) TBAF, rt, 16 h, 35%; (f) t-BuMgCl, phenyl ethoxyalaninyl phosphorochloridate, THF, rt, 18 h, 27%.