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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Eur J Med Chem. 2011 May 30;46(9):3832–3844. doi: 10.1016/j.ejmech.2011.05.051

Scheme 5.

Scheme 5

Synthesis of some l-2-amino 6-substituted 3′-azido purines. Reagents and conditions: (a) i) 2-amino-6-chloropurine, BSA, TMSOTf, acetonitrile, 85 °C, 18 h, 54%; ii) TBAF, THF, 5 h, rt, 27%; (b) t-BuMgCl, phenyl ethoxyalaninyl phosphorochloridate, THF, rt, 18 h, 40%; (c) NaOCH3, CH3OH, 80 °C, 16 h, 71%; (d) NH3/CH3OH, CH3OH, 110 °C, 18 h, 87%; (e) t-BuMgCl, phenyl ethoxyalaninyl phosphorochloridate, THF, rt, 18 h, 60%; (f) methylamine, THF, 80 °C, 18 h, 71%.