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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Eur J Med Chem. 2011 May 30;46(9):3832–3844. doi: 10.1016/j.ejmech.2011.05.051

Table 2.

Cellular pharmacology of l-3′-azidopurine nucleosides.

graphic file with name nihms307598u1.jpg
Cmpd R1 R2 R3 Cellular pharmacology in human PBM Cells
Metabolites detected Amount fmol/106 cells
7 H Cl H 7 7.8
9 H OCH3 H None BLDa
10 H NH2 H 10 4400
10-MP 1400
10-DP 76
10-TP 670
11 H NH2 graphic file with name nihms307598t1.jpg 10 7500
10-MP 4200
10-DP 1200
10-TP 7400
12 H NHCH3 H 12-MP 17
15 NH2 OH H 15 3200
15-MP 46
15-TP 54
17 NH2 Cl H 17 7.6
17-DP 38.3
17-TP BLD
18 NH2 Cl graphic file with name nihms307598t1.jpg 18 12
17 49
17-MP 430
17-DP 190
17-TP 10
20 NH2 NH2 H 20-MP 3.5
20-TP 7.6
a

BLD = below the limit of detection.