Figure 3.

Behavioral analysis of HTT suppression in the putamen. (a) Average counts of homecage, daytime activity were assessed using activity monitors mounted onto collars worn by each animal. No significant differences were detected between groups over time (P > 0.05, repeated measures ANOVA using animal group and time as variables). (b) Body weights taken immediately prior to surgery and at the time of necropsy were not significantly different between groups (P > 0.05). (c) Time course of average latencies to remove treats from (d) a straight metal post indicate no significant differences in performance between the treatment groups (P > 0.05) although all groups significantly increased their speed in removing the treat over the duration of the study (P < 0.001). (f) Average latencies to remove treats from (e,g) a question mark–shaped metal rod indicate no significant differences in performance between groups (P > 0.05). n = 4 animals per group for AAV-miHDS1- and AAV-miCONT-injected animals; n = 3 for AAV-eGFP-injected animals.