. 2012 Jan 1;35(1):41–48. doi: 10.5665/sleep.1582

Table 6.

Previous studies of magnetic resonance spectroscopy in OSA

Reference	N OSA, control	ROI	Findings	Other results	Comment
Kamba²⁷	15,23	Medial parietooccipital cortex, parietoccipital PWM	Decreased NAA/Cho in WM not GM in severe OSA vs mild OSA and control		Multiple comorbidities. OSA patients older.
Kamba²⁸	55,0	Medial parietooccipital cortex, parietoccipital PWM	Decreased NAA/Cho proportional to AHI, independent of age and comorbidity.		No relationship to indices of oxygenation
Bartlett³⁰	8,5	Left hippocampus	Increased NAA/Cr	No correlation with PVT but correlated with arousal index	Felt primarily due to decreased Cr
Alchanatis²⁹	22,10	Frontal PWM, prefrontal GM, parietoccipital PWM.	Decreased NAA/Cr and Cho/Cr frontal white matter	No differences other locations. No correlation with OSA severity.	Some cardiovascular disease. Results the same if these excluded.
Tonon³¹	14,10	Medial parietoccipital cortex	Decreased NAA, unchanged after 6 months CPAP	Correlation with nadir SpO₂ and with MSLT but not neuropsych testing	Careful screening for comorbidity. Patient reported compliance only.
Sarchielli³²	20, 20	Frontal and temporal voxels including both GM and WM	Decreased frontal NAA/Cr, increased temporal Cho/Cr	Frontal changes correlated with AHI

Explanation of terms: ROI, region of interest; PWM, periventricular white matter; GM, gray matter; PVT, psychomotor vigilance task; MSLT, mean latency on multiple sleep latency test.