Table 2.

Characteristics of Prevnar responders and nonresponder

Characteristics	Responder	Nonresponder	Univariate	Multivariate
	N=79	N=48
Median age (range)	15(0.1–59)	40.5(0.7–64)	<0.001	0.001
Sex, male, no. (%)	39(49.4)	30(62.5)	0.20
*Diagnosis, no. (%)			0.03	0.27
Acute Leukemia	37(46.8)	27(56.3)
Chronic Leukemia	4(5.1)	2(4.2)
Aplastic Anemia/MDS	19(24.1)	7(14.6)
NHL/HD	4(5.1)	9(18.8)
Others	15(19.0)	3(6.3)
Graft type, no. (%)			0.46
Unmodified Transplant	37(46.8)	19(39.6)
T Cell depleted Transplant	42(53.2)	29(60.4)
Donor, no. (%)			0.09
HLA-matched related	39(49.4)	28(58.3)
HLA-mismatched related	7(8.8)	0
unrelated	33(41.8)	20(41.7)
TBI regimen, no. (%)	36(45.6)	23(47.9)	0.85
DLI, no. (%)	2(2.6)	10(20.9)	0.001	0.06
Acute GVHD, no (%)	9(11.4)	1(2.1)	0.08
Chronic GVHD, no. (%)	18(22.8)	7(14.6)	0.35
Natural Log
CD4+/CD45RA+
Median(range)	5.0(−4.6–7.1)	4.4(−4.6–6.4)	0.004	0.21

Table 2b. PNCRM7 response in children (upper) and adults (lower)
	Children <18 yrs
	Median age: 9 years
	Range: 0.1–17.9
Overall Response	45/51 (88%)
Transplant type	23/27 (85%)	p=0.67
Unmodified	22/24 ((92%)
T-cell depleted
Donor Type		p=0.40
HLA-matched Related	22/24 (92%
Unrelated	16/20 (80%)
HLA-MM related	7/7 (100%)
HLA-matched related		p=0.53
Unmodified	14/16 (88%)
T- cell depleted	8/8 (100%)
Unrelated donor		p=1.00
Unmodified	8/10 (80%)
T-cell depleted	8/10 (80%)
	Adults ≥18 yrs, Median 41 yrs Range: 18.0–64.0
Overall response	34/76 (44%)
Transplant type		p=0.63
Unmodified	14/29 (48%)
T-cell depleted	20/47 (43%)
Donor Type		p=0.35
Related	17/43 (40%)
Unrelated	17/33 (52%)
HLA-matched related		p=0.20
Unmodified	10/19 (53%)
T-cell depleted	7/23 (30%)
Unrelated donor		p=0.46
Unmodified	4/10 (44%)
T cell depleted	13/23 (57%)